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Anti -AMP Activated Protein Kinase alpha1 (AMPK a1)
Anti -AMP Activated Protein Kinase alpha1 (AMPK a1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| AMPK alpha-1 chain (5'-AMP-activated protein kinase catalytic subunit alpha-1) is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. It appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. It is expressed in kidney, liver, lung, heart, and brain tissues. | | | Catalog # | A1475-01T | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 0.05-0.2ug/ml | | Western Blot: 1.0ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Mouse | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 30% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide TSPPDSFLDDHHLTR conjugated to KLH | | Specificity | Recognizes mouse AMPK alpha-1 chain. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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