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Anti -AMP Activated Protein Kinase alpha2 (5'-AMP-activated Protein Kinase Catalytic Subunit alpha-2, AMPK alpha-2 Chain, AMPK Subunit alpha-2, AMPK a2, AMPK2, PRKAA2, PRKAA)
Anti -AMP Activated Protein Kinase alpha2 (5'-AMP-activated Protein Kinase Catalytic
Subunit alpha-2, AMPK alpha-2 Chain, AMPK Subunit alpha-2, AMPK a2, AMPK2, PRKAA2, PRKAA)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| AMPK2 alpha2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. | | | Catalog # | A1475-02K | | Applications | Suitable for use in ELISA and Western Blot. Other applications have not been tested. | | Recommended Dilutions | | | ELISA: 0.25ug/ml | | Western Blot: 0.5-2.5ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.25mg/ml | | Form | Supplied as a liquid in PBS, 0.09% sodium azide. | | Purity | Purified by Protein G afinity chromatography. | | Immunogen | Synthetic peptide corresponding to the C- terminal region of human AMPK (KLH). | | Specificity | Recognizes human AMPK 2. Species crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | EC=2.7.11.1, Protein Kinase AMP-activated alpha 2 Catalytic Subunit |
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