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You are here:Home » Antibodies » Abs to Protein Kinases » Anti -AMPK1 (5'-AMP-activated Protein Kinase Catalytic Subunit alpha-1, AMPK Subunit alpha-1, PRKAA1)

Anti -AMPK1 (5'-AMP-activated Protein Kinase Catalytic Subunit alpha-1, AMPK Subunit
alpha-1, PRKAA1)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
AMPK1 acts as a central regulator of cellular metabolism for which it serves as an energy sensor, the enzyme is activated by a reduction of ATP/AMP levels, changes in intracellular calcium, and other forms of stress, including ischemia and hypoxia. The protein is at the center of control for a large number of metabolic reactions, thereby playing a crucial role in Type 2 diabetes and other human diseases The protein is also crucial for cell polarity and mitosis as confirmed by recent studies. AMPK1 is thus a key energy sensor, known to regulate energy metabolism in diverse cell types. Structurally heterotrimeric AMPK contains a catalytic alpha-subunit, encoded by two genes (alpha1 and alpha2). The protein is usually present in the nucleus and cytoplasm. Human AMPK1 gene is mapped to chromosomal region 5p12.
Catalog #A1475-06J
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochemistry (paraffin): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic non-phosphopeptide corresponding to human AMPK1 around the phosphorylation site of threonine 174 (L-R-TP-S-C).
SpecificityRecognizes human AMPK1. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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