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Anti -AMPK1 (5'-AMP-activated Protein Kinase Catalytic Subunit alpha-1, AMPK Subunit alpha-1, PRKAA1)
Anti -AMPK1 (5'-AMP-activated Protein Kinase Catalytic Subunit alpha-1, AMPK Subunit
alpha-1, PRKAA1)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
|
| AMPK1 acts as a central regulator of cellular metabolism for which it serves as an energy sensor, the enzyme is activated by a reduction of ATP/AMP levels, changes in intracellular calcium, and other forms of stress, including ischemia and hypoxia. The protein is at the center of control for a large number of metabolic reactions, thereby playing a crucial role in Type 2 diabetes and other human diseases The protein is also crucial for cell polarity and mitosis as confirmed by recent studies. AMPK1 is thus a key energy sensor, known to regulate energy metabolism in diverse cell types. Structurally heterotrimeric AMPK contains a catalytic alpha-subunit, encoded by two genes (alpha1 and alpha2). The protein is usually present in the nucleus and cytoplasm. Human AMPK1 gene is mapped to chromosomal region 5p12. | | | Catalog # | A1475-06J | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:500-1:1000 | | Immunohistochemistry (paraffin): 1:50-1:100 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic non-phosphopeptide corresponding to human AMPK1 around the phosphorylation site of threonine 174 (L-R-TP-S-C). | | Specificity | Recognizes human AMPK1. Species Crossreactivity: mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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