Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -Amphiregulin (AREG, Colorectum Cell-derived Growth Factor, AREGB, AR, SDGF, CRDGF, MGC13647)

Anti -Amphiregulin (AREG, Colorectum Cell-derived Growth Factor, AREGB, AR, SDGF, CRDGF,
MGC13647)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IP
Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84aa residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252aa transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGFa, AR, HB-EGF, cripto-1, epiregulin, and betacellulin. All of these growth factors contain a characteristic EGF-like domain, which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of the breast, colon, stomach, and pancreas.
Catalog #A1585-02B
ApplicationsSuitable for use in Immunoprecipitation. Other applications not tested.
Recommended DilutionImmunoprecipitation: 10ug/mg protein lysate
Optimal dilutions to be determined by the researcher.
Positive ControlLS174T cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to the aa8-26 from human amphiregulin.
SpecificityRecognizes human Amphiregulin. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links