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You are here:Home » Biochemicals » Biochem-Antibiotics » Amphotericin B Solution, 100X (Fungizone, Fungilin, Ampho-Moronal)

Amphotericin B Solution, 100X (Fungizone, Fungilin, Ampho-Moronal)

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Specifications

Amphotericin B is a polyene antifungal agent for yeast, mold and mycoplasma. It was first isolated by Gold, et a., from Streptomyces nodosus in 1955. It is an amphoteric compound composed of a hydrophilic polyhydroxyl chain along one side and a lipophilic polyene hydrocarbon chain on the other. Amphotericin B is poorly soluble in water. Amphotericin B binds to sterols, preferentially to the primary fungal cell membrane sterol, ergosterol. This binding disrupts osmotic integrity of the fungal membrane, resulting in leakage of intracellular potassium, magnesium, sugars, and metabolites and then cellular death.
Catalog #A2230
Used in the preparation of baculoviral stocks.
FormSupplied as an easy to use 100X concentrate.
pH 10-12
Activity 250ug/ml
SterilityAseptically prepared by 0.2um filtration
UsageAdd aseptically 1ml concentrate to 100ml culture medium.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number1397-89-3
Molecular FormulaC47H73NO17
Molecular Weight924.09
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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