Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Neuroscience » Anti -Amylin (DAP, Diabetes-Associated Peptide, IAP, Islet Amyloid Polypeptide, Insulinoma Amyloid Peptide, IAPP)

Anti -Amylin (DAP, Diabetes-Associated Peptide, IAP, Islet Amyloid Polypeptide, Insulinoma
Amyloid Peptide, IAPP)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant IH IF
The calcitonin family of bioactive peptides comprises of calcitonin, amylin, two calcitonin-gene related peptides (CGRP1, and CGRP2) and adrenomedullin (ADM). Amylin is a 37aa peptide produced in the pancreatic beta-cell secretory granules and is co-released with insulin. Amylin also has CGRP-like effects on bone metabolism. Amylin has specific binding sites in the CNS and it may regulate gastric emptying and influence carbohydrate metabolism. The calcitonin family peptides probably act through G-protein coupled membrane receptors. Recently, a homolog of calcitonin receptor, CRLR (calcitonin-receptor-like receptor human 461 aa; rat/mouse 463 aa) was identified. It is now shown that CRLR can function as either a CGRP receptor or an ADM receptor, depending upon which members of a new family of proteins called receptor activity modifying proteins (RAMP1-3) are expressed.
Catalog #A2275-52Y
ApplicationsSuitable for use in Immunohistochemistry and Immunofluorescence. Other applications not tested.
Recommended DilutionsImmunohistochemistry (Paraffin): 1:100. Antigen retrieval is not essential but may optimize staining. Does not require protein digestion pre-treatment or antigen retrieval using heat treatment prior to staining.
Immunohistochemistry (Frozen): 1:100
Immunofluorescence (IC): 1:10-1:2000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8J258
HostMouse
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid, 0.09% sodium azide.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to CATQRLANFLV, internal sequence aa40-50 of human Amylin coupled to tuberculin. Cellular Localization: Cytoplasmic and Secreted
SpecificityRecognizes human Amylin. Stains islet amyloid peptide in intracellular insulin granules, intracellular amyloid and extracellular islet amyloid. Species Sequence Homology: mouse, rat, canine and chinese hamster; 100%, feline, chicken, guinea pig and rabbit; 90%
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links