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You are here:Home » Molecular Biology » MB-Insulin » Amylin, Rat, Control Peptide (DAP, Diabetes-Associated Peptide, IAP, Islet Amyloid Polypeptide, Insulinoma Amyloid Peptide, IAPP)

Amylin, Rat, Control Peptide (DAP, Diabetes-Associated Peptide, IAP, Islet Amyloid
Polypeptide, Insulinoma Amyloid Peptide, IAPP)

Pricing

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Specifications

Control peptide for A2275-53P.
Catalog #A2275-53Q
The calcitonin family of bioactive peptides comprises of calcitonin, amylin, two calcitonin-gene related peptides (CGRP1, and CGRP2) and adrenomedullin (ADM). Amylin is a 37aa peptide produced in the pancreatic beta-cell secretory granules and is co-released with insulin. Amylin also has CGRP-like effects on bone metabolism. Amylin has specific binding sites in the CNS and it may regulate gastric emptying and influence carbohydrate metabolism. The calcitonin family peptides probably act through G-protein coupled membrane receptors. Recently, a homolog of calcitonin receptor, CRLR (calcitonin-receptor-like receptor human 461aa; rat/mouse 463aa) was identified. It is now shown that CRLR can function as either a CGRP receptor or an ADM receptor, depending upon which members of a new family of proteins called receptor activity modifying proteins (RAMP1-3) are expressed.
SourceSynthetic peptide corresponding to 13aa from the ~mid-region of mature of Amylin 18-30aa of rat AMYL/AML (accession #P12969).
Molecular Weight~3kD
ApplicationsSuitable for use in ELISA and Antibody Blocking. Not suitable for Western Blot. Other applications not tested.
Recommended DilutionELISA: 5-10ug control peptide per 1 g of aff pure IgG or 1ul antiserum
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~3kD
SourceSynthetic peptide
PurityPurified
Concentration~1mg/ml
FormSupplied as a lyophilized powder from PBS, 0.05% sodium azide.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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