| Alzheimer’s disease (AD) is characterized by the presence of senile plaques in the brain and blood vessel walls. Amyloid Beta A4 (A 4) protein has been found to be the principal constituent of senile plaques of AD’s patients (1-2). The amyloid beta-protein precursor (APP) is proteolytically cleaved to generate the 4kD A 4 protein. Two variants of A 4 can be detected; A 1-40 “short-tailed” and A 1-42 “long-tailed” (3-4). |
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| Catalog # | A2275-58X |
| Applications | Suitable for use in Flow Cytometry, Western Blotting, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry. Other applications not tested. |
| Recommended Dilution | Flow Cytometry: 1:20 |
| Western Blotting: 1:5,000-20,000 |
| Immunohistochemistry: 1:250-500 |
| Immunocytochemistry:1:250-500 |
| Immunoprecipitation: 1:50 |
| Optimal dilutions to be determined by the researcher. |
| Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
| CAS Number | n/a |
| Clone Type | Monoclonal |
| Isotype | IgG |
| Clone No | 6k24 |
| Host | Rabbit |
| Source | Human |
| Form | Supplied as a liquid |
| Purity | Supernatant |
| Immunogen | A synthetic peptide corresponding to residues in the NPXY motif of human Amyloid Beta A4 precusor (APP) |
| Specificity | Recognizes human Amyloid Beta A4 precusor (APP) |
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| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
| Alternate names | A4, AAA, ABETA, ABPP, AD1, Alzheimer disease amyloid protein, amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease), Amyloid beta A4 protein precursor, APPI, Cerebral vascular amyloid peptide, CTFgamma, CVAP, PN2, PN-II, PreA4, Prote |
