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You are here:Home » Antibodies » Abs to Amyloid » Anti -Amyloid Beta, 1-40 (Amyloid A4)

Anti -Amyloid Beta, 1-40 (Amyloid A4)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites IH
In the brains of patients with Alzheimer's disease, amyloid composed of 4kD amyloid beta protein is deposited in senile plaques and in blood vessel walls. Amyloid beta protein is a 39-43aa polypeptide with heterogeneous termini that is generated from the cleavage of a larger amyloid precursor protein (APP), which under appropriate cellular conditions, aggregate as senile plaques, which is a critical step in the neurodegenerative processes associated with AD. Cleavgae of the transmembrane region of APP by ã-secretase generates a number of isoforms of amyloid beta protein, of 39-43aa residues in length with the most common isoforms being amyloid beta protein 40 and amyloid beta protein 42. The shorter form is typically produced by cleavage that occurs in the endoplasmic reticulum, while the longer form is produced by cleavage in the trans-Golgi network. The amyloid beta protein 40 form is the more common of the two, but amyloid beta protein 42 is the more fibrillogenic and is thus associated with disease states.
Catalog #A2275-59D1
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Positive ControlBrain
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No11E12
HostMouse
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.05% sodium azide.
PurityAscites
ImmunogenSynthetic beta amyloid peptide (1-40) (KLH). Cellular Localization: Cytoplasmic.
SpecificityRecognizes human Amyloid beta Protein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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