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You are here:Home » Antibodies » Abs to Amyloid » Anti -Amyloid Beta, 1-42 (Amyloid A4)

Anti -Amyloid Beta, 1-42 (Amyloid A4)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified B IH
Alzheimer's Disease (AD) is the most common neurodenerative disorder in elderly people. It has been demonstrated that AD has biological cause and is characterized by the presence of senile plaques and neurofibrillary tangles mainly in cerebral cortex and hippocampus brain regions. Amyloid-beta 1-40 (Ab40) and amyloid-beta 1-42 (Ab42) are the main components of the above plaques; however, other forms of amyloid-beta peptides also present. Both peptides are cleaved from the Amyloid Precursor Protein (APP) by b-secretase and g-secretase enzymes. Many studies suggest that Ab42 or/and Ab43 are required to initiate formation of amyloid plaques and neurofibrills that leads to the neurodegeneration.
Catalog #A2275-59D2
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-1ug/ml
Immunohistochemistry: 0.05-0.2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone NoMM26-2.1.3
HostMouse
Concentration~0.1mg/ml
FormSupplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 50% glycerol, 0.1% sodium azide.
PurityPurified
ImmunogenSynthetic peptide corresponding to aa35-42 (MVGGVVIA) of beta-amyloid (1-42).
SpecificityRecognizes beta-amyloid. Species Crossreactivity: human, mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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