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Specifications

Clone Host Grade Applications Monoclonal Mouse Purified B IH

Alzheimer's Disease (AD) is the most common neurodenerative disorder in elderly people. It has been demonstrated that AD has biological cause and is characterized by the presence of senile plaques and neurofibrillary tangles mainly in cerebral cortex and hippocampus brain regions. Amyloid-beta 1-40 (Ab40) and amyloid-beta 1-42 (Ab42) are the main components of the above plaques; however, other forms of amyloid-beta peptides also present. Both peptides are cleaved from the Amyloid Precursor Protein (APP) by b-secretase and g-secretase enzymes. Many studies suggest that Ab42 or/and Ab43 are required to initiate formation of amyloid plaques and neurofibrills that leads to the neurodegeneration.
Catalog #	A2275-59D2
Applications	Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution	Western Blot: 0.5-1ug/ml
	Immunohistochemistry: 0.05-0.2ug/ml
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	MM26-2.1.3
Host	Mouse
Concentration	~0.1mg/ml
Form	Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 50% glycerol, 0.1% sodium azide.
Purity	Purified
Immunogen	Synthetic peptide corresponding to aa35-42 (MVGGVVIA) of beta-amyloid (1-42).
Specificity	Recognizes beta-amyloid. Species Crossreactivity: human, mouse and rat.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.