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You are here:Home » Antibodies » Abs to Amyloid » Anti -Amyloid Beta, aa1-8 (NT) (Amyloid A4)

Anti -Amyloid Beta, aa1-8 (NT) (Amyloid A4)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified B IH Gel
Beta amyloid is a protein that builds up in the brains of persons with Alzheimer's disease, collecting in clumps called plaques or senile plaques. While some researchers question whether beta amyloid is the cause of the dementia, most agree that it is involved in the disruption of thinking that is a hallmark of the disease. In come cases of familial Alzheimer's disease, mutations in genes for the proteins called the presenilins lead to increased product of amyloid. Researchers have been looking at how presenilins-1 in particular contributes to the excess buildup of beta amyloid. Presenilin-1 apparently acts to increase the activity of gamma-secretase, an enzyme that changes a normal protein (amyloid precursor protein or APP) into beta amyloid itself. Presenilin-1 might be gamma-secretase.
Catalog #A2275-59P
ApplicationsSuitable for use in Dot Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionDot Blot: 1:100-1:1,000
Immunohistochemistry: 1:100-1:1,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No9L29
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS.
PurityPurified by ammonium sulfate precipitation.
ImmunogenSynthetic peptide NAEFRHDSGYQVHHQKLVFFAEDV corresponding to 1-24aa of human beta amyloid.
SpecificityRecognizes the amino terminal region (aa1-8) of human beta amyloid peptide. Highly reactive to Amyloid beta form of APP.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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