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You are here:Home » Antibodies » Abs to Amyloid » Anti -Amyloid A, Serum (Serum Amyloid A, SAA)

Anti -Amyloid A, Serum (Serum Amyloid A, SAA)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
Human Serum Amyloid A protein-1 (SAA1) is a multifunctional apolipoprotein produced by hepatocytes in response to proinflammatory cytokines. It is secreted as a 12kD, 104aa, nonglycosylated polypeptide that displaces apoA1 in the HDL3 complex. The SAA1 gene is one of three SAA genes in human, and it shows multiple alleles that are race dependent. The SAA1 gene product differs from the SAA2 gene product by only 7aa. Circulating SAA1 shows multiple proteolytically-generated isoforms, with anywhere from one-to-three aas being cleaved from either the N- or C-terminus. Mature human SAA1 is 72%, 82% and 72% aa identical to mature mouse, rabbit and hamster SAA1, respectively.
Catalog #A2275-60B5
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:5,000
ELISA: 1:5,000-1:20,000
Optimal dilutions to be determined by the researcher.
HybridomaSp2/0 myeloma cells with spleen cells from Balb/c mice.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG
Clone No11C77
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a lyophilized powder from PBS, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to human SAA protein.
SpecificityRecognizes human SAA. No reactivity against normal human plasma, Apo AI and Apo AII. Species sequence homology: mouse and hamster (72%) and rabbit (82%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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