Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Amyloid » Anti -Amyloid A Component

Anti -Amyloid A Component

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant IH
Amyloid A is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60-promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. It also acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. The protein is expressed in all fetal tissues, with highest levels in brain, kidney, heart and spleen. Multiple transcript variants encoding ten different isoforms have been found for the gene encoding Amyloid A protein. Mutations in the gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Catalog #A2275-61B
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry (Formalin/paraffin): 1:100-1:200 for 20 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 minutes followed by cooling at RT for 20 minutes.
Positive ControlAmyloid deposits in kidney.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a,k
Clone No5G6
HostMouse
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid, 0.09% sodium azide
PurityTissue culture supernatant
ImmunogenHuman amyloid A. Cellular Localization: Extracellular
SpecificityRecognizes isolated human protein A in both native fibril form and denatured form. It also recognizes amyloid deposits in all organs and tissues including kidney and rectum, as well as the serum precursor of protein A.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links