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Anti -Amyloid beta A3 Precursor Protein (APBA3, X11- , Adaptor protein X11 gamma, Mint3, X11L2)
Anti -Amyloid beta A3 Precursor Protein (APBA3, X11- , Adaptor protein X11 gamma, Mint3,
X11L2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Sheep |
Affinity Purified |
E B |
|
| X11- (Adaptor protein X11 gamma; also APBA3, Mint3 and X11L2) is a member of the X11 family of adaptor proteins. Unlike X11- and - which are generally neuronal proteins, X11- is widely expressed in all tissues. X11- has many functions, including MT-MMP and Furin intracellular trafficking and APP binding. Human X11- is 575 amino acids (aa) in length. It contains a poly-Ser segment (aa165-171), a PID region (aa217-381) that binds -amyloid | | | precursor, and two PDZ domains (aa393-478 and 485-560) that bind Arf GTPases. There is one potential splice variant that shows a 34 aa insertion after Ile505. Over aa1-138, human X11- shares 62% aa identity with mouse X11- . | | | Catalog # | A2275-61H | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 0.5-1ug/ml | | Western Blot:1ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Cell lysates were resolved by SDS-PAGE, transferred to an Immobilon-P membrane and | | immunoblotted with 1ug/ml sheep anti-human APBA3. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute by adding sterile 40-50% glycerol, PBS, 0.02% sodium azide. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Sheep | | Source | Human | | Concentration | As reported | | Form | Supplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with 100ul sterile 40-50% glycerol, PBS, 0.02% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Recombinant corresponding to aa1-138 of human APBA3 (E. coli). | | Specificity | Recognizes human APBA3. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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