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You are here:Home » Antibodies » Abs to Apoptosis » Anti -Amyloid beta A3 Precursor Protein (APBA3, X11- , Adaptor protein X11 gamma, Mint3, X11L2)

Anti -Amyloid beta A3 Precursor Protein (APBA3, X11- , Adaptor protein X11 gamma, Mint3,
X11L2)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Sheep Affinity Purified E B
X11- (Adaptor protein X11 gamma; also APBA3, Mint3 and X11L2) is a member of the X11 family of adaptor proteins. Unlike X11- and - which are generally neuronal proteins, X11- is widely expressed in all tissues. X11- has many functions, including MT-MMP and Furin intracellular trafficking and APP binding. Human X11- is 575 amino acids (aa) in length. It contains a poly-Ser segment (aa165-171), a PID region (aa217-381) that binds -amyloid
precursor, and two PDZ domains (aa393-478 and 485-560) that bind Arf GTPases. There is one potential splice variant that shows a 34 aa insertion after Ile505. Over aa1-138, human X11- shares 62% aa identity with mouse X11- .
Catalog #A2275-61H
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 0.5-1ug/ml
Western Blot:1ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlCell lysates were resolved by SDS-PAGE, transferred to an Immobilon-P membrane and
immunoblotted with 1ug/ml sheep anti-human APBA3.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute by adding sterile 40-50% glycerol, PBS, 0.02% sodium azide. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostSheep
SourceHuman
ConcentrationAs reported
FormSupplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with 100ul sterile 40-50% glycerol, PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to aa1-138 of human APBA3 (E. coli).
SpecificityRecognizes human APBA3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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