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Anti -Amyloid beta A4 Precursor Protein-Binding, Family B, Member 1 (APBB1, Fe65, MGC:9072, RIR, Adaptor Protein FE65a2, Stat-like Protein)
Anti -Amyloid beta A4 Precursor Protein-Binding, Family B, Member 1 (APBB1, Fe65,
MGC:9072, RIR, Adaptor Protein FE65a2, Stat-like Protein)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B |
|
| The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene but some of their full length sequence is not known. | | | Catalog # | A2275-61P | | Positive Control | NIH/3T3 lysate | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:128,000. | | Western Blot: ~ 100kD band observed in lysates of NIH/3T3 and HeLa (calculated MW of 77.2kD according to NP_001155. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | | | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris-saline, pH 7.2, 0.5% BSA. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide, CGSLKPKRLGAHTP, representing the C Terminus of the human protein according to NP_001155.1; NP_663722.1. Homology: Human | | Specificity | Species Crossreactivity: Human and mouse. Other species not tested. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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