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You are here:Home » Antibodies » Abs to Amyloid » Anti -Amyloid Precursor Protein (APP, Amyloid beta (A4) Precursor Protein)

Anti -Amyloid Precursor Protein (APP, Amyloid beta (A4) Precursor Protein)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Amyloid precursor protein (APP) is a type I integral membrane protein with a large N-terminal extracellular domain, a single transmembrane domain, and a short cytoplasmic tail. APP can be sequentially cleaved by beta-secretase and gamma-secretase to release beta-amyloid, which is the main component of senile plaque in patient brains inflicted with Alzheimer's disease.
Amyloid Precursor Protein (Ab-730) Polyclonal Antibody is developed in rabbit using the synthesized peptide derived from human APP around the phosphorylation site of serine 730 (Y-T-SP-I-H).
Catalog #A2275-69J
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 0.05-0.2ug/ml
Western Blot: 0.1-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityFor long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 30% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthesized peptide derived from human APP around the phosphorylation site of serine 730 (Y-T-SP-I-H).
SpecificityRecognizes endogenous level of mouse APP.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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