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You are here:Home » Antibodies » Abs to Amyloid » Anti -Amyloid Precursor Protein (APP, Amyloid beta (A4) Precursor Protein)

Anti -Amyloid Precursor Protein (APP, Amyloid beta (A4) Precursor Protein)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Serum E B IH
Amyloid Precursor Protein IS a 130kD member of the APP family, expressed in adult brain. It is a cell surface kinesin I membrane receptor which regulates the axonal transport of beta-secretase and presenilin 1.In Alzheimer's disease processing of APP by beta-secretase gives rise to amyloidogenic 42 AA beta amyloid protein that is found in senile plaques and vessels. APP binds components of the extracellular matrix such as heparin and collagen I and IV, regulating neurite growth and is also involved in neuronal adhesion, cell mobility and axonogenesis. Through itís binding to APBB1/Tip60, APP plays a role in the regulation of transcription. APP also inhibits Notch signaling through itís interaction with NUMB.
Catalog #A2275-69V
ApplicationsSuitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications not tested.
Recommended DilutionsELISA: 1:1500
Immunohistochemistry (Frozen): 1:5,000
Immunohistochemistry (Paraffin): 1:100
Western Blot: 1:1000. Detects a band of ~130kD in neuronal cell lysates.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid, 0.09% sodium azide
PuritySerum
ImmunogenSynthetic peptide corresponding to the aa44-63 of human amyloid precursor protein (Swiss Prot #P05067)
SpecificityRecognizes human Amyloid Precursor Protein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesA4, AAA, ABETA, ABPP, AD1, Alzheimer Disease Amyloid Protein, Amyloid beta (A4) Precursor Protein (Peptidase Nexin-II, Alzheimer Disease), Amyloid beta A4 Protein Precursor, APPI, Cerebral Vascular Amyloid Peptide, CTFgamma, CVAP, PN2, PN-II, PreA4, Prote


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