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You are here:Home » Antibodies » Abs to Amyloid » Anti -Amyloid Precursor Protein (APP, Amyloid beta (A4) Precursor Protein)

Anti -Amyloid Precursor Protein (APP, Amyloid beta (A4) Precursor Protein)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Serum E B IH
In Alzheimer's disease, APP is broken down and releases the 12 amino acid b-amyloid protein that is found in senile plaques and vessels. The amyloid precursor protein is the subject of intensive investigations to determine how this protein is broken down abnormally in Alzheimer's disease to give rise to the b-amyloid protein which is present in senile plaques and vessels. This antiserum has been shown to be immunoreactive to the immunizing peptide by ELISA. The antiserum will immunolabel dystrophic neurites in senile plaques in both formalin-fixed paraffin sections and paraformaldehyde fixed frozen sections from Alzheimer's brain. This antiserum should be a valuable tool for scientist and neuropathologists who study the role of amyloid in Alzheimers's disease.
Catalog #A2275-71A
ApplicationsSuitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications have not been tested.
Recommended DilutionsELISA: 1:1500 against immunogen peptide
Immunohistochemistry (Frozen): 1:2500-1:5000 detected APP on 4% paraformaldehyde fixed frozen sections.
Immunohistochemistry (Parrafin): 1:50-1:100 detcted APP on formalin fixed paraffin embedded tissue.
Western Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid, 0.01% thimerosal.
PuritySerum
ImmunogenPeptide corresponding aa44-63 from the N-terminal region of the human Amyloid Precursor Protein.
SpecificityRecognizes the human Amyloid Precursor Protein (APP). Immunolabels dystrophic neurites in senile plaques in both formalin-fixed paraffin sections and paraformaldehyde fixed frozen sections from Alzheimer’s brain.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesA4, AAA, ABETA, ABPP, AD1, Alzheimer disease amyloid protein, amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease), Amyloid beta A4 protein precursor, APPI, Cerebral vascular amyloid peptide, CTFgamma, CVAP, PN2, PN-II, PreA4, Prote


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