You are here:Home
»
Antibodies
»
Abs to Amyloid
»
Anti -Amyloid Precursor Protein, Kpi Domain (APP, Amyloid beta (A4) Precursor Protein)
Anti -Amyloid Precursor Protein, Kpi Domain (APP, Amyloid beta (A4) Precursor Protein)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
E B |
|
| Amyloid Precursor Protein (APP) is an integral membrane protein with a large ectodomain, a transmembrane domain, and a short cytoplasmic tail. APP is proteolytically cleaved by b-secretase (BACE) to generate the APP N-terminal fragment (sbAPP) with Mr100kD and a C-terminal fragment (C99) with Mr12kD. The smaller 12kD fragment can be further cleaved by g-secretase, an enzyme activity recently attributed to presenilin-2. This second cleavage produces the insoluble b-amyloid (Ab), a peptide of ~4kD. The accumulation of b-amyloid in intracellular neurofibrillary tangles and extracellular plaques is observed in the brains of Alzheimer’s disease patients and Downs’s Syndrome patients. | | | Catalog # | A2275-71F | | Applications | Suitable for use in ELISA and Western Blot. Other applications have not been tested. | | Recommended Dilutions | ELISA: 1:500 | | Western Blot: 1:150 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid, 0.1% sodium azide, before the addition of glycerol to 40%. | | Purity | Serum | | Immunogen | Synthetic peptide that corresponds to a part of KPI Domain in soluble APP | | Specificity | Recognizes soluble Amyloid Precursor Protein (APP) and synthetic peptide corresponding to a part of KPI Domain in soluble APP by ELISA. It recognizes soluble APP with Western blot analysis. SSpecies Crossreactivity: Human. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
