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Anti -Amyloid Precursor Protein, Kpi Domain (APP, Amyloid beta (A4) Precursor Protein)
Anti -Amyloid Precursor Protein, Kpi Domain (APP, Amyloid beta (A4) Precursor Protein)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| Amyloid Precursor Protein (APP) is an integral membrane protein with a large ectodomain, a transmembrane domain, and a short cytoplasmic tail. APP is proteolytically cleaved by b-secretase (BACE) to generate the APP N-terminal fragment (sbAPP) with Mr100kD and a C-terminal fragment (C99) with Mr12kD. The smaller 12kD fragment can be further cleaved by g-secretase, an enzyme activity recently attributed to presenilin-2. This second cleavage produces the insoluble b-amyloid (Ab), a peptide of ~4kD. The accumulation of b-amyloid in intracellular neurofibrillary tangles and extracellular plaques is observed in the brains of Alzheimer’s disease patients and Downs’s Syndrome patients. | | | Catalog # | A2275-71G | | Application(s) | ELISA: 10ug/ml. ED50 – 300ng/ml | | Western blot: 10ug/ml | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide. | | Purity | Affinity Purified | | Immunogen | Synthetic peptide that corresponds to a part of KPI Domain in soluble APP | | Specificity | Recognizes soluble Amyloid Precursor Protein (APP) and synthetic peptide corresponding to a part of KPI Domain in soluble APP by ELISA. Recognizes soluble APP with Western blot. Species Reactivity: Human. | | | Important Note | This product is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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