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You are here:Home » Antibodies » Abs to Amyloid » Anti -Amyloid Precursor Protein, Universal (uAPP)

Anti -Amyloid Precursor Protein, Universal (uAPP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IP
Amyloid Precursor Protein (APP) is an integral membrane protein with a large ectodomain, a transmembrane domain, and a short cytoplasmic tail. APP is proteolytically cleaved by b-secretase (BACE) to generate the APP N-terminal fragment (sbAPP) with Mr100kD and a C-terminal fragment (C99) with Mr12kD. The smaller 12kD fragment can be further cleaved by g-secretase, an enzyme activity recently attributed to presenilin-2. This second cleavage produces the insoluble b-amyloid (Ab), a peptide of ~4kD. The accumulation of b-amyloid in intracellular neurofibrillary tangles and extracellular plaques is observed in the brains of Alzheimer’s disease patients and Downs’s Syndrome patients.
Catalog #A2275-71J
Application(s)Western blot: 1:250 – 1:1000
Immunoprecipitation: Need to reduce and alkylate disulfide bonds.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder, no preservatives. Reconstitute with 500ul distilled water.
PuritySerum
ImmunogenAPP (aa 99–126) conjugated to KLH
SpecificityRecognizes the immature APP, a protein with Mr95kD and also the APP holoprotein, a posttranslationally modified protein with Mr100-120kD. Specific to amino acids 99–126. Species crossreactivity: Monkey, mouse. Does not react with bovine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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