Anti -APBA1 (Amyloid beta (A4) precursor protein-binding, family A, member 1, Adapter
protein X11alpha, amyloid beta (A4) precursor protein-binding, family A, member 1 (X11),
Amyloid beta A4 precursor protein-binding family A member 1, D9S411E, MINT1, Mint-1, N
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B |
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| Amyloid Precursor Protein (APP) is an integral membrane protein with a large ectodomain, a transmembrane domain, and a short cytoplasmic tail. APP is proteolytically cleaved by b-secretase (BACE) to generate the APP N-terminal fragment (sbAPP) with Mr 100kD and a C-terminal fragment (C99) with Mr 12kD. The smaller 12kD fragment can be further cleaved by g-secretase, an enzyme activity recently attributed to presenilin-2. This second cleavage produces the insoluble b-amyloid (Ab), a peptide of ~4kD. The accumulation of b-amyloid in intracellular neurofibrillary tangles and extracellular plaques is observed in the brains of Alzheimer’s disease patients and Downs’s Syndrome patients. | | | Catalog # | A2275-71K | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:16000 | | Western Blot: 0.1-0.3ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Goat | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in Tris-saline, pH 7.2, 0.5% BSA, 0.02% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide of APBA1. | | Specificity | Recognizes APBA1 at ~100kD in human brain (cerebellum and hippocampus) lysates (calculated MW of 92.9kD according to NP_001154.2). Species Crossreactivity: Mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -APBA1 (Amyloid beta (A4) precursor protein-binding, family A, member 1, Adapter protein X11alpha, amyloid beta (A4) precursor protein-binding, family A, member 1 (X11), Amyloid beta A4 precursor protein-binding family A member 1, D9S411E, MINT1, Mint-1, N |
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