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You are here:Home » Antibodies » Antibodies-Apoptosis » Anti -Amyloid Precursor Protein Frameshift Mutant (APP, Amyloid beta (A4) Precursor Protein)

Anti -Amyloid Precursor Protein Frameshift Mutant (APP, Amyloid beta (A4) Precursor


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Clone Host Grade Applications
Polyclonal Goat Serum B IH
Catalog #A2275-71N
ApplicationsSuitable for use in Immunohistochemistry and Western Blot. Other applications have not been tested.
Recommended DilutionImmunohistochemistry: Paraffin. 1:300
Western Blot: 1:3000
Optimal working dilutions to be determined by researcher.
Immunohistochemistry Recommended Positive Control Tissue: AD Brain, Aged Brain.
Recommended Secondary ReagentsDonkey anti-SheepGoat IgG: HRP
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
ConcentrationNot determined
FormSerum. Supplied as a liquid with 0.1% sodium azide.
ImmunogenSynthetic peptide corresponding to amino acids 339-348 of the C-terminus of APP frameshift mutant.
SpecificityBinds to the truncated amyloid precursor protein frameshift mutant, which results from a GA dinucleotide deletion from the normal APP gene. This abnormal protein has been found to accumulate in the brains of some patients with Alzheimer's disease. This reagent labels dystrophic neurites in senile plaques of brains from AD patients following formalin fixation.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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