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Anti -Amyloid Precursor Protein Frameshift Mutant (APP, Amyloid beta (A4) Precursor Protein) Pricing   For pricing information, USA customers sign in.   Outside USA? Please contact your distributor for pricing. Specifications Clone Host Grade Applications Polyclonal Goat Serum B IH Catalog # A2275-71N Applications Suitable for use in Immunohistochemistry and Western Blot. Other applications have not been tested. Recommended Dilution Immunohistochemistry: Paraffin. 1:300 Western Blot: 1:3000 Optimal working dilutions to be determined by researcher. Immunohistochemistry Recommended Positive Control Tissue: AD Brain, Aged Brain. Recommended Secondary Reagents Donkey anti-SheepGoat IgG: HRP Storage and Stability May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Clone Type Polyclonal Isotype IgG Host Goat Source Human Concentration Not determined Form Serum. Supplied as a liquid with 0.1% sodium azide. Purity Serum. Immunogen Synthetic peptide corresponding to amino acids 339-348 of the C-terminus of APP frameshift mutant. Specificity Binds to the truncated amyloid precursor protein frameshift mutant, which results from a GA dinucleotide deletion from the normal APP gene. This abnormal protein has been found to accumulate in the brains of some patients with Alzheimer's disease. This reagent labels dystrophic neurites in senile plaques of brains from AD patients following formalin fixation. Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.    Questions or comments about this product? Inquire here.    Download Specifications for Anti -Amyloid Precursor Protein Frameshift Mutant (APP, Amyloid beta (A4) Precursor Protein) External Links Search PubMed. Search Google Scholar.