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Anti -Amyloid Precursor Protein, 737-751 (APP, Amyloid beta (A4) Precursor Protein)
Anti -Amyloid Precursor Protein, 737-751 (APP, Amyloid beta (A4) Precursor Protein)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
|
| Accumulation of the amyloid-beta peptide (A-beta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. The beta-amyloid protein precursor (APP) is cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-aa carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4kD amyloid-beta peptide. | | | Catalog # | A2275-71U | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1-2ug/ml | | Immunohistochemistry: 2ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa737-751 of human amyloid A4 protein precursor (APP) or 85-99 of the C99 fragment generated by beta-secretase cleavage. | | Specificity | Recognizes human Amyloid Precursor Protein (APP) and C99. Species Crossreactivity: mouse, rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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