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Specifications

Clone Host Grade Applications Polyclonal Rabbit Serum E IH

Amyloid b (Ab) accumulates in the senile plaques of the brain during Alzheimer’s disease and during certain classes of cerebrovascular angiopathy. Ab generation is initiated by proteolytic cleavage of the Amyloid Precursor Protein (APP) by b-secretase (BACE) at a site which corresponds to the Ab N terminus. A second proteolytic cleavage by g-secretase at a site corresponding to the Ab C terminus releases the Ab peptide. The insoluble Ab peptide forms aggregates in the vessels and senile plaques of Alzheimer’s disease brains.
Catalog #	A2275-73B
Applications	Suitable for use in ELISA and Immunohistochemistry (formalin fixed and paraffin embedded sections). Other applications not tested.
Recommended Dilution	ELISA: 1:1,000
	Immunohistochemistry: 1:200
	Optimal dilutions to be determined by the researcher.
Positive Control	Alzheimer’s disease brain.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	Not determined
Form	Supplied as a liquid in 0.1% sodium azide.
Purity	Processed whole rabbit serum.
Immunogen	A synthetic peptide corresponding to aa sequence 1-14 (1DAEFRHDSGYEVHH14) of the human amyloid b protein.
Specificity	Recognizes Amyloid b peptide. Species Reactivity: Human. Will discriminate amyloid b from other CNS amyloids.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.