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You are here:Home » Antibodies » Abs to Amyloid » Anti - -Amyloid (1-40), CT

Anti - -Amyloid (1-40), CT

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E B IC
The beta-amyloid peptide (beta A4), proteolytically released from the amyloid precursor protein (APP), is the principal component of senile plaques in Alzheimer's disease. Cleavage of APP by alpha-secretase or alternatively by beta-secretase leads to generation and extracellular release of soluble APP peptides, S-APP-alpha and S-APP-beta, respectively, and the retention of corresponding membrane-anchored C-terminal fragments, C83 and C99. Subsequent processing of C83 by gamma-secretase yields P3 peptides. This is the major secretory pathway and is nonamyloidogenic. Alternatively, presenilin/nicastrin-mediated gamma-secretase processing of C99 releases the amyloid beta proteins, amyloid-beta 40 (Abeta40) and amyloid-beta 42 (Abeta42), major components of amyloid plaques, and the cytotoxic C-terminal fragments, gamma-CTF(50), gamma-CTF(57) and gamma-CTF(59).
Catalog #A2275-73Q
Applications
Suitable for use in ELISA, Immunocytochemistry and Western Blot. Other applications not tested.
Recommended DilutionELISA: 0.1ug/ml.
Western Blot: 1ug/ml for for HRPO/ECL detection
Immunocytochemistry: 1-10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No6D3
HostMouse
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.09% sodium azide, PEG and sucrose.
PurityPurified by subsequent thiophilic adsorption and seize exclusion chromatgraphy.
ImmunogenC-terminal peptide of human beta-amyloid (KLH coupled).
SpecificityRecognizes the C-terminus of human beta-amyloid (aa 1-40 isoform). Does not cross-react with beta-amyloid (aa 1-42 isoform).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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