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You are here:Home » Antibodies » Abs to Amyloid » Anti - -Amyloid, aa8-17

Anti - -Amyloid, aa8-17

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant IH
Amyloid beta-protein/amyloid A4 or amyloid beta-peptide is derived from the amyloid beta-precursor protein. Beta amyloid is an extracellular filamentous protein deposit found in the
brain. It is the major protein component of amyloid cores, neuritic plaques and is also found as a deposit in neurofibrillary tangles. In man, Alzheimer’s disease is the most common cause of senile dementia and is characterized by abnormal filamentous protein deposits in the brain. Beta amyloid deposits are also detected in Lewy body dementia, Down’s syndrome, amyloidosis (Dutch type) and in the Guam
Parkinson-Dementia complex.
Catalog #A2275-74
ApplicationsSuitable for use in Immunohistochemistry. Other applications have not been tested.
Recommended DilutionImmunohistochemistry (formalin/paraffin only): 1:25-1:50 for 60 min at RT.
Note: Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min., followed by cooling at RT for 20 min.
Optimal dilutions to be determined by the researcher.
Positive ControlHuman brain of Alzheimer’s disease.
Cellular LocalizationTransmembrane (APP) and extracellular (amyloid b).
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No0.N.28
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as liquid in 0.09% sodium azide.
PurityTissue culture supernatant
ImmunogenSynthetic peptide corresponding to residues 8-17 (SGYEVHHQKL) of the amyloid beta-protein/amyloid A4 which is the same as aa660-669 of human amyloid A4/amyloid b protein precursor.
SpecificityReacts with a human 4-5kD peptide derived from the amyloid beta-precursor protein. Species Crossreactivity: Human
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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