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You are here:Home » Antibodies » Antibodies-Amyloid » Anti -Amyloid Beta, 1-43 (CT) (Amyloid A4)

Anti -Amyloid Beta, 1-43 (CT) (Amyloid A4)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Alzheimer's Disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major component of these plaques is Ab peptide (b-amyloid), a 40 to 43aa peptide cleaved from amyloid precursor protein (APP). Increased release of the 'longer forms' of Ab peptide, Ab42 or Ab43, which have a greater tendency to aggregate than Ab40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alleles, or may involve other, still undiscovered, factors. Many researchers theorize that this increased release of Ab42/Ab43 leads to the abnormal deposition of Ab and the associated neurotoxicity in the brains of affected individuals.
Catalog #A2275-74H4
ApplicationsSuitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:500
Western Blot: 1:100-1:1,000
Immunohistochemistry (paraffin): 1:100-1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone No9L31
FormSupplied as a liquid in PBS. No preservative added.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to the last 6aa of ABx-43 (KLH).
SpecificityRecognizes the C-terminus of beta amyloid and specific for the isoform ending at the 43rd amino acid.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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