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You are here:Home » Antibodies » Abs to Amyloid » Anti - -Amyloid 1-40

Anti - -Amyloid 1-40

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B
Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognition in the elderly. One of the most important and initial step involves proteolytic cleavage of amyloid precursor protein (APP, chromosome 21) releasing short 40, 42 and 43aa peptides (beta amyloid 1-40, 1-42, and 1-43). Polymerization of b-amyloid (Ab) and subsequent neuronal deposit (amyloid) leads to the degeneration of neurons involved in memory and cognition. Ab deposits have also been found to contain 2 additional proteins termed a-synuclein and b-synuclein. The 140aa a-synucleins is identical with non- Ab component (NACP) of AD. The 134aa human b-synuclein is homologous to 14kD bovine phosphoneuroprotein. Mutations in a-synuclein gene causing a replacement of alanine with a threonine may cause the protein to misfold. Synucleins are primarily expressed in the brain. At least 3 forms: two large (140aa SYN-1 and 149aa SYN-2) and a small form (SYN-3, 42aa) are produced by alternative splicing.
Catalog #A2275-74L
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-1:50000
ELISA: 1:10,000-1:100,000.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, 0.05% sodium azide.
PuritySerum
ImmunogenHuman beta Amyloid 1-40 synthetic C-terminal 7 aa peptide conjugated to KLH.
SpecificityRecognizes human b-amyloid. Demonstrates a high degree of homology with human and murine b-amyloid (1-40) and b-amyloid (1-42). Weak crossreactivity is observed with b-amyloid (1-28) and b-amyloid (12-28). No crossreaction is observed with CGRP. Species crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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