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You are here:Home » Antibodies » Abs to Amyloid » Anti - -Amyloid 1-40, 42, CT

Anti - -Amyloid 1-40, 42, CT

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E B IC
The beta-amyloid peptide (beta A4), proteolytically released from the amyloid precursor protein (APP), is the principal component of senile plaques in Alzheimer's disease. Cleavage of APP by alpha-secretase or alternatively by beta-secretase leads to generation and extracellular release of soluble APP peptides, S-APP-alpha and S-APP-beta, respectively, and
the retention of corresponding membrane-anchored C-terminal fragments, C83 and C99. Subsequent processing of C83 by gamma-secretase yields P3 peptides. This is the major
secretory pathway and is nonamyloidogenic. Alternatively, presenilin/nicastrin-mediated gamma-secretase processing of C99 releases the amyloid beta proteins, amyloid-beta 40
(Abeta40) and amyloid-beta 42 (Abeta42), major components of amyloid plaques, and the cytotoxic C-terminal fragments, gamma-CTF(50), gamma-CTF(57) and gamma-CTF(59).
Catalog #A2275-75L
Applications
Suitable for use in ELISA, Immunocytochemistry and Western Blot. Other applications have not been tested.
Recommended DilutionsELISA: 0.05ug/ml
Western Blot: 1ug/ml for HRPO/ECL detection. Block with Casein/Tween 20 based blocking and blot incubation buffer.
Immunocytochemistry: 0.1-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
IsotypeIgG1
Clone No6D4
HostMouse
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in 2X PBS, 0.1% sodium azide, PEG, sucrose.
PurityPurified by size exclusion chromatography.
ImmunogenSynthetic peptide corresponding to aa1-40 and aa1-42 of C-terminal human b-amyloid, conjugated to KLH.
SpecificityRecognizes human C-terminal b-amyloid (aa1-40 and aa1-42). Crossreactivity: APP.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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