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You are here:Home » Antibodies » Abs to Amyloid » Anti -Amyloid Beta, 1-42 (CT) (Amyloid A4)

Anti -Amyloid Beta, 1-42 (CT) (Amyloid A4)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Alzheimers disease (AD) is characterized by the presence of senile plaques in the brain and blood vessel walls. Amyloid Beta A4 (Ab4) protein has been found to be the principal constituent of senile plaques of ADs patients. The amyloid beta-protein precursor (APP) is proteolytically cleaved to generate the 4kD Ab4 protein. Two variants of Ab4 can be detected; Ab-40 short-tailed and Ab-42 long-tailed.
Catalog #A2275-75N
ApplicationsSuitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 1:100-1:1000
Immunohistochemistry (FFPE): 1:100-1:2000. Pretreat sections with 70% formic acid for 10-30 minutes. Antibody should be incubated with sections overnight at 4ºC.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No9L34
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.4. No stabilizing proteins or preservative added.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to the last 6aa of ABx-42 conjugated to KLH through the addition of an N-terminal cysteine.
SpecificityRecognizes the C-terminus of human beta amyloid and is specific for the isoform ending at the 42nd amino acid. Species Crossreactivity: mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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