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Specifications

Clone Host Grade Applications Monoclonal Mouse Purified E B IC

Amyloid beta-protein/amyloid A4 or amyloid beta-peptide is derived from the amyloid beta-precursor protein. Beta amyloid is an extracellular filamentous protein deposit found in the brain. It is the major protein component of amyloid cores, neuritic plaques and is also found as a deposit in neurofibrillary tangles. In man, Alzheimer’s disease is the most common cause of senile dementia and is characterized by abnormal filamentous protein deposits in the brain. Beta amyloid deposits are also detected in Lewy body dementia, Down’s syndrome, amyloidosis (Dutch type) and in the Guam Parkinson-Dementia complex.
Catalog #	A2275-75W
Applications	Suitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested.
Recommended Dilution	ELISA: 0.05ug/ml
	Immunocytochemistry: 0.1-1ug/ml
	Western Blot: 1ug/ml for HRP/ECL detection
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	6D5
Host	Mouse
Source	Human
Concentration	~0.1mg/ml
Form	Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, PEG, sucrose.
Purity	Purified by subsequent thiophilic adsorbtion and size exclusion chromatography.
Immunogen	Synthetic peptide corresponding to aa1-42 of C-terminal human b-amyloid (KLH).
Specificity	Recognizes the C-terminus of human b-amyloid aa1-42 isoform. Does not cross-react with b-amyloid aa1-40 isoform.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.