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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified E IC

The beta-amyloid peptide (beta A4), proteolytically released from the amyloid precursor protein (APP), is the principal component of senile plaques in Alzheimer's disease. Cleavage of APP by alpha-secretase or alternatively by beta secretase leads to generation and extracellular release of soluble APP peptides, S-APP-alpha and S-APP beta, respectively, and the retention of corresponding membrane-anchored C-terminal fragments, C83 and C99. Subsequent processing of C83 by gamma-secretase yields P3 peptides. This is the major secretory pathway and is nonamyloidogenic. Alternatively, presenilin/nicastrin-mediated gamma-secretase processing of C99 releases the amyloid beta proteins, amyloid-beta 40 (Abeta40) and amyloid-beta 42 (Abeta42), major components of amyloid plaques, and the cytotoxic C-terminal fragments, gamma-CTF(50), gamma- CTF(57) and gamma-CTF(59).
Catalog #	A2275-75W2
Applications	Suitable for use in Immunocytochemistry. Other applications have not been tested.
Recommended Dilutions
	Immunocytochemistry: 1-10ug/ml
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	6D5
Host	Mouse
Source	Human
Concentration	~0.5mg/ml
Form	Supplied as a liquid in PBS, 0.09% sodium azide, PEG and sucrose. Labeled with FITC.
Purity	Purified by subsequent thiophilic adsorption and size exclusion chromatography.
Immunogen	Synthetic peptide corresponding to aa 1-42 of C-terminal human beta-amyloid (KLH).
Specificity	Recognizes the C-terminus of human beta-amyloid (aa1-42 isoform). Does not cross-react with beta-amyloid (aa1-40 isoform).
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.