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You are here:Home » Antibodies » Abs to Amyloid » Anti - -Amyloid (1-42), CT (FITC)

Anti - -Amyloid (1-42), CT (FITC)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E IC
The beta-amyloid peptide (beta A4), proteolytically released from the amyloid precursor protein (APP), is the principal component of senile plaques in Alzheimer's disease. Cleavage of APP by alpha-secretase or alternatively by beta secretase leads to generation and extracellular release of soluble APP peptides, S-APP-alpha and S-APP beta, respectively, and the retention of corresponding membrane-anchored C-terminal fragments, C83 and C99. Subsequent processing of C83 by gamma-secretase yields P3 peptides. This is the major secretory pathway and is nonamyloidogenic. Alternatively, presenilin/nicastrin-mediated gamma-secretase processing of C99 releases the amyloid beta proteins, amyloid-beta 40 (Abeta40) and amyloid-beta 42 (Abeta42), major components of amyloid plaques, and the cytotoxic C-terminal fragments, gamma-CTF(50), gamma- CTF(57) and gamma-CTF(59).
Catalog #A2275-75W2
ApplicationsSuitable for use in Immunocytochemistry. Other applications have not been tested.
Recommended Dilutions
Immunocytochemistry: 1-10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG1
Clone No6D5
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.09% sodium azide, PEG and sucrose. Labeled with FITC.
PurityPurified by subsequent thiophilic adsorption and size exclusion chromatography.
ImmunogenSynthetic peptide corresponding to aa 1-42 of C-terminal human beta-amyloid (KLH).
SpecificityRecognizes the C-terminus of human beta-amyloid (aa1-42 isoform). Does not cross-react with beta-amyloid (aa1-40 isoform).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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