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You are here:Home » Antibodies » Abs to Amyloid » Anti - -Amyloid Peptide-binding protein (BBP)

Anti - -Amyloid Peptide-binding protein (BBP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
Both genetic and biochemical data have established that b-anyloid peptide (Ab) is a causative factor in neuronal death and the consequent diminuation of cognitive abilities observed in Alzheimer’s disease.1,2 Plasma lipoproteins and their cell surface receptors influence sequestration and clearance on soluble Ab, contributing to the etiology of the disease.3,4 Ab may act as an initiating factor in the death of neurons by inducing signal pathways leading to apoptosis.5,6 b-amyloid peptide-binding protein (BBP) is a novel protein containing a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily that is important in heterotrimeric G protein activation.7 BBP binds human b-amyloid peptide in vitro with high affinity and specificity. Expression of BBP in cell culture induces caspase-dependent vulnerability to b-amyloid peptide toxicity, suggesting that BBP mediates this cellular vulnerability through a G protein-regulated program of cell death. 7
Catalog #A2275-76E
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1-3ug/ml
Immunoprecipitation (native): 7ug/reaction
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide, before the addition of glycerol to 40%.
PurityPurified by immunoaffinity chromatography
ImmunogenSynthetic peptide derived from the N-terminal region of the human Beta-amyloid peptide binding protein (BBP).
SpecificityRecognizes the human BBP proteins On Western blots, it identifies up to three bands at ~35kD, ~45kD, and ~50kD. The multiple bands may be due to various glycosylation sites and/or isoforms. Reactivity has been confirmed with human NGP neuroblastoma cell lysates, placental homogenates, and mouse and rat brain homogenates. Species Crossreactivity: Mouse and rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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