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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified E IP IH

Amyloid beta-protein/amyloid A4 or amyloid beta-peptide is derived from the amyloid beta-precursor protein. Beta amyloid is an extracellular filamentous protein deposit found in the
brain. It is the major protein component of amyloid cores, neuritic plaques and is also found as a deposit in neurofibrillary tangles. In man, Alzheimer’s disease is the most common cause of senile dementia and is characterized by abnormal filamentous protein deposits in the brain. Beta amyloid deposits are also detected in Lewy body dementia, Down’s syndrome, amyloidosis (Dutch type) and in the Guam
Parkinson-Dementia complex.
Catalog #	A2275-78A
Applications	Suitable for use in ELISA, Immunohistochemisry and Immunoprecipitation. Not suitable for Western Blot. Other applications not tested.
Recommended Dilutions	Immunohistochemistry (paraffin): Requires protein digestion pre-treatment of paraffin sections using formic acid for 2-3 minutes. (Detects extracellular amyloid beta with senile plaques and vessel amyloid in Alzheimer's disease brain.)
	Optimal dilutions to be determined by the researcher.
Recommended Secondary Antibody	I1904-65W: IgG, F(ab’)2 (HRP) Pab RbxMo
	I1904-66C: IgG, F(ab’)2, X-Adsorbed (HRP) Pab RbxMo
Recommended Positive Control Tissue	Alzheimer's disease brain
Recommended Negative Controls	I1904-78R: IgG1 Murine Negative Control
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	3H532
Host	Mouse
Source	Human
Concentration	~1mg/ml
Form	Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
Purity	Purified by Protein G affinity chromatography.
Immunogen	Synthetic peptide consisting of residues 1 - 17 of the amyloid beta protein.
Specificity	Recognizes the human beta amyloid peptide, which is the major protein component of the amyloid cores in neuritic plaques.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.