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You are here:Home » Molecular Biology » MB-Apoptosis » Amyloid Precursor Protein, CT (APP)

Amyloid Precursor Protein, CT (APP)

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Specifications

Amyloid Precursor Protein (APP) is an integral membrane protein with a large ectodomain, a transmembrane domain, and a short cytoplasmic tail. APP is proteolytically cleaved by b-secretase (BACE) to generate the APP N-terminal fragment (sbAPP) with Mr100kD and a C-terminal fragment (C99) with Mr12kD. The smaller 12kD fragment can be further cleaved by g-secretase, an enzyme activity recently attributed to presenilin-2. This second cleavage produces the insoluble b-amyloid (Ab), a peptide of ~4kD. The accumulation of b-amyloid in intracellular neurofibrillary tangles and extracellular plaques is observed in the brains of Alzheimer's disease patients and Downs's Syndrome patients.
Catalog #A2275-82A
In Alzheimer's disease, this protein is broken down and releases the 12aa beta-amyloid protein that is found in senile plaques and vessels. The amyloid precursor protein is currently investigationed to determine how this protein is broken down abnormally in Alzheimer's disease to give rise to the beta-amyloid protein which is present in senile plaques and vessels.
Source
Synthetic peptide corresponding to aa681-695, GYENPTYKFFEQMQN of Amyloid Precursor Protein (CT) Peptide.
ApplicationsSuitable for use in ELISA. Other applications not tested
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and Stability:
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceSynthetic
Purity~55% pure (Ion Spray Mass Spectrometry)
FormSupplied as a lyophilized powder. Reconstitute in sterile distilled water.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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