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You are here:Home » Antibodies » Antibodies-Amyloid » Anti - -Amyloid Protein Precursor, A4 (APP)

Anti - -Amyloid Protein Precursor, A4 (APP)


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Clone Host Grade Applications
Polyclonal Rabbit Serum B
A large body of evidence has implicated the amyloid precursor protein (APP) in the pathogenesis of Alzheimer's disease (AD). The phosphorylation APP at Thr668 is thought to play a critical role in generation of the soluble APP (beta) and beta-amyloid peptide (abeta) which are the major components of senile plaques in patient brains inflicted with AD.
Catalog #A2275-83E
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
ConcentrationNot determined
FormSupplied as a liquid (serum)
ImmunogenPeptide corresponding to amino acid residues from the C-terminal region of rat APP
SpecificityRecognizes rat APP (Mr~115k). Immunolabeling of the APP protein band is completely blocked by preadsorption of the antibody with the peptide used as antigen. Species Crossreactivity: canine, human, mouse, and non-human primates based on 100% antigen sequence homology.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesAAA, ABETA, ABPP, AD1, Alzheimer disease, Amyloid beta A4 protein precursor isoform b, Amyloid beta A4 protein precursor isoform c, Amyloid beta-peptide, APPI, Cerebral vascular amyloid peptide, CVAP, PN2

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