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You are here:Home » Antibodies » Abs to Amyloid » Anti -APP, NT (Amyloid beta A4 Protein, APP, ABPP, Alzheimer Disease Amyloid Protein, Cerebral Vascular Amyloid Peptide, CVAP, Protease Nexin-II, PN-II, APPI, PreA4, A4, AD1)

Anti -APP, NT (Amyloid beta A4 Protein, APP, ABPP, Alzheimer Disease Amyloid Protein,
Cerebral Vascular Amyloid Peptide, CVAP, Protease Nexin-II, PN-II, APPI, PreA4, A4, AD1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified E B IH FC
APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Catalog #A2275-85P
ApplicationsSuitable for use in ELISA, Flow Cytometry, Western Blot, and Immunohistochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 1:1000
Immunohistochemistry (FFPE): 1:10-1:50
Flow Cytometry: 1:10-1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs Reported
FormSupplied as a liquid in PBS, 0.09% sodium azide
PurityPurified by ammonium sulfate precipitation
ImmunogenKLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 29-61 in the N-terminal region of human APP, UniProt Accession #P05067.
Species Sequence HomologyMonkey
SpecificityRecognizes human APP.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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