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You are here:Home » Antibodies » Abs to Amyloid » Anti -Amyloid Precursor Protein (Amyloid beta (A4) Precursor Protein, APP, ABPP, Amyloid beta A4 Protein, Alzheimer Disease Amyloid A4 Protein Homolog, Amyloidogenic Glycoprotein, AG)

Anti -Amyloid Precursor Protein (Amyloid beta (A4) Precursor Protein, APP, ABPP, Amyloid
beta A4 Protein, Alzheimer Disease Amyloid A4 Protein Homolog, Amyloidogenic Glycoprotein,
AG)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
A large body of evidence has implicated the amyloid precursor protein (APP) in the pathogenesis of Alzheimer's disease (AD) (Kamenetz et al., 2003). The phosphorylation APP at Thr668 is thought to play a critical role in generation of the soluble APP (beta) and beta-amyloid peptide (abeta) which are the major components of senile plaques in patient brains inflicted with AD (Liu et al., 2003; Ando et al., 2001).
Catalog #A2275-86B
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlRat brain and hippocampus lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
ConcentrationNot determined
FormSupplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 100ug per ml BSA, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenPeptide corresponding to amino acid residues from the C-terminal region of rat APP.
SpecificityRecognizes rat APP. Species Sequence Homology: canine, human and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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