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You are here:Home » Molecular Biology » MB-Amyloid » -Amyloid Protein 42, Recombinant, Human (ABPP, APPI, APP, Alzheimer Disease Amyloid Protein, Cerebral Vascular Amyloid Peptide, CVAP, PreA4, Protease Nexin-II, PN-II, APP, A4, AD1)

-Amyloid Protein 42, Recombinant, Human (ABPP, APPI, APP, Alzheimer Disease Amyloid
Protein, Cerebral Vascular Amyloid Peptide, CVAP, PreA4, Protease Nexin-II, PN-II, APP,
A4, AD1)

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Specifications

Beta-amyloid (Abeta) peptides result from the proteolytic cleavage of beta-amyloid precursor protein (APP) which is encoded by a gene located on chromosome 21. Abeta is produced by two proteases (beta- and gamma- secretase) and has vary forms (39- and 43-mer peptides). Abeta40 and Abeta42 peptides are major constituents of the plaques and tangles that occur in Alzheimer's disease (AD). Abeta42 plays a critical role in the pathogenesis of AD since its aggregative ability and neurotoxicity are much greater than these of Abeta40. Abeta42 oligomers initially formed as a seed accelerate the aggregation of Abeta40 to form the amyloid plaques that eventually lead to the neurodegeneration (amyloid cascade hypothesis). Abeta40 also serves as an antioxidant molecule by quenching metal ions and inhibiting metal-mediated oxygen radical generation.
Catalog #A2275-86G
SourceRecombinant corresponding to aa1-42, with N-GST tag, from human beta-Amyloid 42, expressed in E.coli.
Molecular Weight~31kD
Storage and StabilityAliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight~31kD
SourceE.coli
Purity~95% (SDS-PAGE)
Concentration~1mg/ml
FormSupplied as a liquid in 20mM HEPES, pH 7.0, 10% glycerol.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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