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You are here:Home » Antibodies » Abs to Amyloid » Anti -APP, Phosphorylated (Thr668) (Amyloid beta A4 Protein, ABPP, APPI, Alzheimer Disease Amyloid Protein, Cerebral Vascular Amyloid Peptide, CVAP, PreA4, Protease Nexin-II, PN-II, A4, AD1)

Anti -APP, Phosphorylated (Thr668) (Amyloid beta A4 Protein, ABPP, APPI, Alzheimer Disease
Amyloid Protein, Cerebral Vascular Amyloid Peptide, CVAP, PreA4, Protease Nexin-II, PN-II,
A4, AD1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Amyloid beta (A4) Precursor Protein (APP) is a ubiquitously expressed transmembrane protein that is sequentially cleaved by beta-secretase and gamma-secretase to release extracellular peptides such as the b-amyloid peptides, which are deposited in the brain in Alzheimer's disease. APP exists in several isoforms ranging from 100-140kD, and is phosphorylated on various residues within the extracellular and cytoplasmic domains, effecting the proteolytic processing and secretion of the protein. Threonine 668 can be phosphorylated by cyclin-dependent kinase 5 (cdk5), GSK-3b and JNK, and may play an important role in neurite outgrowth of differentiating neurons.
Catalog #A2275-86Q
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.1-1ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlCAD cells transfected with wild type vs. T668A mutant APP
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to the region of human APP that contains threonine 668 (corresponding to the APP695 isoform).
SpecificityRecognizes human APP when phosphorylated at Thr668. Species Crossreactivity: mouse, rat, and frog.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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