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You are here:Home » Antibodies » Abs to Amyloid » Anti -APP (Amyloid beta A4 Protein, ABPP, APPI, Alzheimer Disease Amyloid Protein, Cerebral Vascular Amyloid Peptide, CVAP, PreA4, Protease Nexin-II, PN-II, A4, AD1)

Anti -APP (Amyloid beta A4 Protein, ABPP, APPI, Alzheimer Disease Amyloid Protein,
Cerebral Vascular Amyloid Peptide, CVAP, PreA4, Protease Nexin-II, PN-II, A4, AD1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
This amyloid beta A4 protein precursor (APP) gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides (reviewed in 1). Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60-promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer 's disease. Mutations in the APP gene have been found in autosomal dominant Alzheimer's disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple mRNA transcript variants encoding several different APP isoforms have been described.
Catalog #A2275-87Q
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.05% sodium azide, 50% glycerol.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa653-665 (RPGSGLTNIKTEE) of human amyloid beta A4 protein precursor, isoform a; Genbank accession no. NP_000475.1.
SpecificityRecognizes human APP. Species sequence homology: canine, macaque, mouse, rat, xenopus.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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