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A2275-87Z1 Rabbit Anti-Amyloid Precursor Protein (APP) (epitope b)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Shipping Temp
Blue Ice
Storage Temp
-20°C

Amyloid precursor protein (APP) is a cell surface receptor and transmembrane precursor protein that undergoes extensive proteolytic processing by secretases to promote the neurite growth, neuronal adhesion, axonogenesis and transcriptional activation. In Alzheimer disease, APP protein is broken down and releases the amyloid- beta-peptide that is found in senile plaques and vessels.

Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Synthetic peptide (GYENPTYKFFEQMQN) corresponding to aa681-695 of C-terminal human APP (APP695 isoform)
Form
Supplied as a liquid in PBS, pH 7.2.
Purity
Purified by Protein G affinity chromatography.
Specificity
Recognizes human Amyloid Precursor Protein
References
Reinhard, C. et al. (2005) EMBO J. 24,3996 - 4006. Selkoe, D.J. (2001) Physiol. Rev. 81,741 - 766. Kosic, K.S. (1999) Proc. Natl. Acad. Sci. U.S.A. 96,2574 - 2576.
USBio References
No references available
Conjugates
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