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You are here:Home » Antibodies » Abs to Amyloid » Anti -Amyloid P Component, Serum (SAP, APCS, PTX2, mature chain 204aa, chromosome 1q21-23)

Anti -Amyloid P Component, Serum (SAP, APCS, PTX2, mature chain 204aa, chromosome 1q21-23)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B
Serum amyloid P component or SAP or APCS, or PTX2 (mature chain 204 aa, chromosome 1q21-23) with which CRP has about 59% homology, is situated in the same area of chromosome 1. SAP is universally present in amyloid deposits, senile plaque and neurofibrially tangels in Alzheimer’s patients. SAP levels in CSF can be useful for assessing cognitive impairment in AD patients. However, SAP appeared not to be required for A-beta deposition since no endogenous SAP immunoreactivity was found in mice overexpressing APP.
In mice with a targeted deletion of the SAP gene, induction of reactive amyloidosis was retarded, demonstrating the participation of SAP in pathogenesis of amyloidosis in vivo and confirming that inhibition of SAP binding to amyloid fibrils is an attractive therapeutic target. SAP knock out mice develop antinuclear autoimmunity and glomerulonephritis. However the exact role of SAP in SLE is not clear. SAP also neutralizes LPS and it is potentially useful in defense against serious gram-negative sepsis.
Catalog #A2275-88H
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionsELISA: 1:5000-1:20,000
Western Blot: 1:500-1:5000
Optimal dilutions to be determined by the researcher.
Recommended ControlA2275-88F: Amyloid P Component, Serum, Human (SAP, APCS, PTX2, mature chain 204aa, chromosome 1q21-23)
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in PBS, pH 7.4.
PuritySerum
ImmunogenHuman SAP purified from acute phase serum. Native form ~235kD. Monomer ~25kD.
SpecificityRecognizes human SAP. Does not crossreact with CRP or other pentraxins. Species Crossreactivity: Demonstrates minimal crossreactivity with mouse SAP.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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