Anti -Amyloid P Component, Serum, Human (SAP, APCS, PTX2, mature chain 204aa, chromosome
1q21-23)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B |
|
| Serum amyloid P component or SAP or APCS, or PTX2 (mature chain 204 aa, chromosome 1q21-23) with which CRP has about 59% homology, is situated in the same area of chromosome 1. SAP is universally present in amyloid deposits 9senile plaque and neurofibrially tangels) in Alzheimers patients. SAP levels in CSF can be useful for assessing cognitive impairment in AD patients. However, SAP appeared not to be required for A-beta deposition since no endogenous SAP immunoreactivity was found in mice overexpressing APP. | | | In mice with a targeted deletion of the SAP gene, induction of reactive amyloidosis was retarded, demonstrating the participation of SAP in pathogenesis of amyloidosis in vivo and confirming that inhibition of SAP binding to amyloid fibrils is an attractive therapeutic target. SAP knock out mice develop antinuclear autoimmunity and glomerulonephritis. However the exact role of SAP in SLE is not clear. SAP also neutralizes LPS and it is potentially useful in defense against serious gram-negative sepsis. | | | Catalog # | A2275-88J | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilutions | ELISA: 1:500-1:20,000 | | Western Blot: 1:500-1:5000 | | Optimal dilutions to be determined by the researcher. | | Control Peptide | A2275-88F: Amyloid P Component, Serum, Human (SAP, APCS, PTX2, mature chain 204aa, chromosome 1q21-23) | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 3H48 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS. | | Purity | Purified by Protein A/G affinity chromatography. | | Immunogen | Human SAP purified from acute phase serum. Native form ~235kD. Monomer ~25kD | | Specificity | Recognizes human SAP. Does not crossreact with CRP or other pentraxins. Species Crossreactivity: minimal crossreactivity with mouse SAP. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
