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You are here:Home » Antibodies » Abs to Amyloid » Anti -Amyloid P Component, Serum, Human (SAP, APCS, PTX2, mature chain 204aa, chromosome 1q21-23)

Anti -Amyloid P Component, Serum, Human (SAP, APCS, PTX2, mature chain 204aa, chromosome
1q21-23)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
Serum amyloid P component or SAP or APCS, or PTX2 (mature chain 204 aa, chromosome 1q21-23) with which CRP has about 59% homology, is situated in the same area of chromosome 1. SAP is universally present in amyloid deposits 9senile plaque and neurofibrially tangels) in Alzheimers patients. SAP levels in CSF can be useful for assessing cognitive impairment in AD patients. However, SAP appeared not to be required for A-beta deposition since no endogenous SAP immunoreactivity was found in mice overexpressing APP.
In mice with a targeted deletion of the SAP gene, induction of reactive amyloidosis was retarded, demonstrating the participation of SAP in pathogenesis of amyloidosis in vivo and confirming that inhibition of SAP binding to amyloid fibrils is an attractive therapeutic target. SAP knock out mice develop antinuclear autoimmunity and glomerulonephritis. However the exact role of SAP in SLE is not clear. SAP also neutralizes LPS and it is potentially useful in defense against serious gram-negative sepsis.
Catalog #A2275-88J
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionsELISA: 1:500-1:20,000
Western Blot: 1:500-1:5000
Optimal dilutions to be determined by the researcher.
Control PeptideA2275-88F: Amyloid P Component, Serum, Human (SAP, APCS, PTX2, mature chain 204aa, chromosome 1q21-23)
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
IsotypeIgG1
Clone No3H48
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenHuman SAP purified from acute phase serum. Native form ~235kD. Monomer ~25kD
SpecificityRecognizes human SAP. Does not crossreact with CRP or other pentraxins. Species Crossreactivity: minimal crossreactivity with mouse SAP.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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