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You are here:Home » Antibodies » Abs to Serum Proteins » Anti -Amyloid P Component, Serum (SAP, APCS, PTX2, mature chain 204aa, chromosome 1q21-23)

Anti -Amyloid P Component, Serum (SAP, APCS, PTX2, mature chain 204aa, chromosome 1q21-23)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Serum Amyloid P component (SAP) is a non-fibrillar plasma glycoprotein that belongs to the pentraxin family. It is universally found in amyloid deposits (such as senile plaque and neurofibrially tangles in Alzheimers patients), and this is probably due to its specific calcium-dependent binding to motifs, which are present on all types of amyloid fibrils. SAP is also found to prevent fibrillar breakdown by enzymes and it is believed that it helps maintains stability of the amyloid deposits. It has been shown that SAP binds monocytes with high avidity, but does not bind to erythrocytes, NK cells, T-lymphocytes, or B-lymphocytes. SAP production can be induced by exposure to IL-1, IL-6, and IFN-beta. SAP levels in CSF can be useful for assessing cognitive impairment in AD patients.
Catalog #A2275-88P
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionsELISA: 0.05-0.2ug/ml
Western Blot: 0.1-1.0ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to residues near the N-terminus of human serum amyloid P-component conjugated to KLH.
SpecificityRecognizes human serum amyloid P component. Species Crossreactivity: mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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