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Anti -Anaplastic Lymphoma Kinase (ALK, p80)
Anti -Anaplastic Lymphoma Kinase (ALK, p80)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Supernatant |
IH |
|
| Anaplastic large-cell lymphoma (Ki-1 lymphoma) is one of the more commonly occurring forms of T cell lymphoma in humans. The majority of these tumors (> 60%) are associated with a t (2; 5) (p23; q35) chromosomal translocation, which results in an abnormal fusion gene involving the ALK gene and the nucleophosmin (NPM) gene (located on chromosome 5q35), which codes for a ubiquitously expressed nucleolar phosphoprotein that functions in transporting components of ribosomes between the cytoplasm and nucleolus during the final stages of ribosome assembly. Transcription of this abnormal NPM-ALK fusion gene results in the production of an abnormal protein, called p80 that functions as a protein tyrosine kinase and as a potent oncogene. The protein functions through Ras-dependent pathways, which is evident from a direct physical association between the p80 and phosphotyrosine binding Src homology adaptor proteins Grb2, Shc, and IRS-i. | | | Catalog # | A2277-02D | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry: Paraffin; recommended to incubate for 60 min at RT. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11E14 | | Host | Mouse | | Concentration | Not determined | | Form | Supplied as a liquid. | | Purity | Supernatant | | Immunogen | Prokaryotic recombinant corresponding to a region which spans the tyrosine kinase catalytic domain and part of the C-terminus of NPM-ALK transcript (aa419-520). | | Specificity | Recognizes human ALK. Species Crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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