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You are here:Home » Antibodies » Abs to Receptors » Anti -Anaplastic Lymphoma Kinase (ALK, p80)

Anti -Anaplastic Lymphoma Kinase (ALK, p80)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant IH
Anaplastic large-cell lymphoma (Ki-1 lymphoma) is one of the more commonly occurring forms of T cell lymphoma in humans. The majority of these tumors (> 60%) are associated with a t (2; 5) (p23; q35) chromosomal translocation, which results in an abnormal fusion gene involving the ALK gene and the nucleophosmin (NPM) gene (located on chromosome 5q35), which codes for a ubiquitously expressed nucleolar phosphoprotein that functions in transporting components of ribosomes between the cytoplasm and nucleolus during the final stages of ribosome assembly. Transcription of this abnormal NPM-ALK fusion gene results in the production of an abnormal protein, called p80 that functions as a protein tyrosine kinase and as a potent oncogene. The protein functions through Ras-dependent pathways, which is evident from a direct physical association between the p80 and phosphotyrosine binding Src homology adaptor proteins Grb2, Shc, and IRS-i.
Catalog #A2277-02D
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: Paraffin; recommended to incubate for 60 min at RT.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No11E14
HostMouse
ConcentrationNot determined
FormSupplied as a liquid.
PuritySupernatant
ImmunogenProkaryotic recombinant corresponding to a region which spans the tyrosine kinase catalytic domain and part of the C-terminus of NPM-ALK transcript (aa419-520).
SpecificityRecognizes human ALK. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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