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You are here:Home » Antibodies » Abs to Receptors » Anti -Androgen Receptor (Dihydrotestosterone Receptor, Nuclear Receptor Subfamily 3 Group C Member 4, AR, DHTR, NR3C4)

Anti -Androgen Receptor (Dihydrotestosterone Receptor, Nuclear Receptor Subfamily 3 Group
C Member 4, AR, DHTR, NR3C4)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites E B IH
AR (Androgen receptor) is a 99kD (predicted) member of the NR3 subfamily, nuclear hormone receptor family of proteins. Due to a high number of Gln and Pro residues, it runs anomalously at 100-120kD in SDS-Page. It is widely expressed, being found in neurons, endothelial cells, osteoblasts, chrondrocytes, mascrophages, adipocytes, and prostate epithelium. Human AR is 919aa in length. It contains three discrete domains: a "modulating" N-terminus (aa1-553) that is rich in Gln, Pro and Gly, a Zn-finger DNA-binding region (aa554-635), and a ligand-binding domain (aa672-917). AR is highly polymorphic at the N-terminus, with total Gln and Gly residues differing by seven or more residues among individuals. Multiple potential splice forms exist, including an alternative start site at Met189 and a sevenaa substitution foraa1-538 that generates a 45kD isoform. AR does homodimerize, apparently with multiple isotypes.
Catalog #A2281-01F
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:10,000
Western Blot: 1:500-1:2000
Immunohistochemistry (Formalin fixed paraffin embedded): 1:200
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No2H8
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid, 0.03% sodium azide.
PurityAscites
ImmunogenRecombinant corresponding to human AR.
SpecificityRecognizes human AR.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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