Anti -Androgen Receptor (Dihydrotestosterone Receptor, Nuclear Receptor Subfamily 3 Group
C Member 4, AR, DHTR, NR3C4)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Ascites |
E B IH |
|
| AR (Androgen receptor) is a 99kD (predicted) member of the NR3 subfamily, nuclear hormone receptor family of proteins. Due to a high number of Gln and Pro residues, it runs anomalously at 100-120kD in SDS-Page. It is widely expressed, being found in neurons, endothelial cells, osteoblasts, chrondrocytes, mascrophages, adipocytes, and prostate epithelium. Human AR is 919aa in length. It contains three discrete domains: a "modulating" N-terminus (aa1-553) that is rich in Gln, Pro and Gly, a Zn-finger DNA-binding region (aa554-635), and a ligand-binding domain (aa672-917). AR is highly polymorphic at the N-terminus, with total Gln and Gly residues differing by seven or more residues among individuals. Multiple potential splice forms exist, including an alternative start site at Met189 and a sevenaa substitution foraa1-538 that generates a 45kD isoform. AR does homodimerize, apparently with multiple isotypes. | | | Catalog # | A2281-01F | | Applications | Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | ELISA: 1:10,000 | | Western Blot: 1:500-1:2000 | | Immunohistochemistry (Formalin fixed paraffin embedded): 1:200 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 2H8 | | Host | Mouse | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid, 0.03% sodium azide. | | Purity | Ascites | | Immunogen | Recombinant corresponding to human AR. | | Specificity | Recognizes human AR. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
