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You are here:Home » Antibodies » Abs to Receptors » Anti -Androgen Receptor (AR, DHTR, Dihydrotestosterone Receptor, NR3C4, Nuclear receptor subfamily 3 Group C Member 4)

Anti -Androgen Receptor (AR, DHTR, Dihydrotestosterone Receptor, NR3C4, Nuclear receptor
subfamily 3 Group C Member 4)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IH
The Androgen Receptor (AR) is a 90kD steroid hormone receptor that is critical for the development and function of the male reproductive system. AR binding to testosterone or 5a-dihydrotestosterone (DHT) triggers receptor dimerization followed by translocation to the nucleus where it promotes transcription of androgen responsive genes. Multiple polymorphisms in AR are linked to the development of prostate cancer. The ligand binding domain of human AR aa661-920 shares aa sequence identity with mouse and rat AR.
Catalog #A2281-13C
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Paraffin): 8-25ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2A
Clone No11n5
HostMouse
SourceHuman
Concentration~0.5mg/ml (after reconstitution)
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with 200ul sterile PBS.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenRecombinant corresponding to aa660-919 from human Androgen R/NR3C4 expressed in E. coli (P10275).
SpecificityRecognizes human Androgen R/NR3C4. Species Crossreactivity: mouse and rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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